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US Patent 12129280 Oncolytic adenoviruses for treating cancer

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Is a
Patent
Patent
1

Patent attributes

Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
1
Patent Number
121292801
Patent Inventor Names
Sònia Guedan Carrió1
Ramon Alemany Bonastre1
Manel Maria Cascallo Piqueras1
Date of Patent
October 29, 2024
1
Patent Application Number
164052851
Date Filed
May 7, 2019
1
Patent Citations
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US Patent 7109029 Vector constructs
1
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US Patent 7253150 Gene delivery vehicle expressing the aptosis-inducing proteins VP2 and/or apoptin
1
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US Patent 7261885 Adenoviral vector with replication-dependent transgene expression
1
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US Patent 7297542 Adenovirus vector containing a heterologous peptide epitope in the hi loop of the fiber knob
1
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US Patent 7767429 Soluble hyaluronidase glycoprotein (sHASEGP), process for preparing the same, uses and pharmaceutical compositions comprising thereof
1
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US Patent 7902441 Chromosome 3p21.3 genes are tumor suppressors
1
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US Patent 7807618 Methods and compositions for delivering enzymes and nucleic acid molecules to brain, bone and other tissues
1
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US Patent 10316065 Oncolytic adenoviruses for treating cancer
1
...
Patent Primary Examiner
‌
Maria Marvich
1
Patent abstract

The invention is related to an oncolytic adenovirus that comprises a sequence encoding a hyaluronidase enzyme inserted in its genome. This adenovirus spreads more efficiently in the tumour mass and therefore the oncolytic effect is increased. Injecting the oncolytic adenovirus of the invention endovenously, tumour volume regressions are obtained. Therefore the oncolytic adenovirus of the present invention is useful for the treatment of a cancer or a pre-malignant state of cancer.

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