Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Ramon Alemany Bonastre0
Manel Maria Cascallo Piqueras0
Sònia Guedan Carrió0
Date of Patent
June 11, 2019
Patent Application Number
13318876
Date Filed
May 5, 2010
Patent Citations Received
Patent Primary Examiner
Patent abstract
The invention is related to an oncolytic adenovirus that comprises a sequence encoding a hyaluronidase enzyme inserted in its genome. This adenovirus spreads more efficiently in the tumour mass and therefore the oncolytic effect is increased. Injecting the oncolytic adenovirus of the invention endovenously results in tumour volume regressions. Therefore, the oncolytic adenovirus of the present invention is useful for the treatment of a cancer or a pre-malignant state of cancer.
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