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US Patent 11708412 Methods for treating hematologic cancers

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 US Patent 11708412 Methods for treating hematologic cancers

Article

The present invention relates to methods of treating hematologic cancers using a combination of inhibitors of PD-1 or PD-L1 and TIM-3, LAG-3 or CTLA4.

Infobox
Is a
Patent
Patent
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
117084120
Date of Patent
July 25, 2023
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Patent Application Number
167247590
Date Filed
December 23, 2019
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Patent Citations
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US Patent 7101550 PD-1, a receptor for B7-4, and uses therefor
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US Patent 7105328 Methods for screening for compounds that modulate pd-1 signaling
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US Patent 7122372 Peptide useful in immunomodulation
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US Patent 7169791 Inhibitors of tyrosine kinases
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US Patent 7172750 Compositions and methods for the treatment and diagnosis of immune disorders
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US Patent 7329639 Peptide useful in immunomodulation
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US Patent 7332582 Humanized immunomodulatory monoclonal antibodies for the treatment of neoplastic disease or immunodeficiency
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US Patent 7414171 PD-1-lacking mouse and use thereof
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US Patent 7423128 Anti-properdin antibodies, and methods for making and using same
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US Patent 7449300 Detection of antibodies specific for B7-H1 in subjects with diseases or pathological conditions mediated by activated T cells
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US Patent 7470428 Compositions and methods related to TIM-3, a Th1-specific cell surface molecule
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US Patent 7488802 Antibodies against PD-1
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US Patent 7521051 Methods of upmodulating adaptive immune response using anti-PD-1 antibodies
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US Patent 7524498 Human immunomodulatory monoclonal antibodies for the treatment of cancer
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US Patent 7553939 T cell regulatory genes and methods of use thereof
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US Patent 7563869 Substance specific to human PD-1
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US Patent 7595048 Method for treatment of cancer by inhibiting the immunosuppressive signal induced by PD-1
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US Patent 7598257 Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as janus kinase inhibitors
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US Patent 7635757 B7-4 Antibodies and uses therefor
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US Patent 7695715 Monoclonal antibodies, antigens and diagnosis and therapy of malignant diseases
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US Patent 7722868 Agents that modulate the interaction of B7-1 polypeptide with PD-L1 and methods of use thereof
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US Patent 7767675 Imidazotriazines and imidazopyrimidines as kinase inhibitors
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US Patent 7794710 Methods of enhancing T cell responsiveness
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US Patent 7838220 T cell regulatory genes associated with immune disease
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US Patent 7858746 Substance that specifically recognizes PD-1
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US Patent 7943743 Human monoclonal antibodies to programmed death ligand 1 (PD-L1)
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US Patent 8008449 Human monoclonal antibodies to programmed death 1 (PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics
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US Patent 8039273 β-glucuronide-linker drug conjugates
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US Patent 8039479 Compounds and compositions as protein kinase inhibitors
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US Patent 8088905 Nucleic acids encoding antibodies against PD-1
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US Patent 8101176 Compositions and methods related to TIM-3, a TH1-specific cell surface molecule
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US Patent 8168179 Treatment method using anti-PD-L1 antibody
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US Patent 8168757 PD-1 binding proteins
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US Patent 8217149 Anti-PD-L1 antibodies, compositions and articles of manufacture
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US Patent 8287856 PD-1 antibodies in combination with a cytokine-secreting cell and methods of use thereof
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US Patent 8329660 Tim-3 ligands and methods thereof
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US Patent 8354509 Antibodies to human programmed death receptor PD-1
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US Patent 8361736 Ex vivo methods for targeting or depleting acute myeloid leukemia cancer stem cells
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US Patent 8415355 Pyrrolopyrimidine compounds and their uses
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US Patent 8460886 Use of an efficacy marker for optimizing therapeutic efficacy of an anti-human PD-1 antibody on cancers
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US Patent 8460927 B7-H1 antibodies and method of use
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US Patent 8461330 Imidazotriazines and imidazopyrimidines as kinase inhibitors
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US Patent 8501758 Compounds and compositions as protein kinase inhibitors
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US Patent 8546336 SMAC peptidometics useful as IAP inhibitors
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US Patent 8546396 N-(hetero)aryl, 2-(hetero)aryl—substituted acetamides for use as Wnt signaling modulators
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US Patent 8552002 Compounds and compositions as protein kinase inhibitors
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US Patent 8552154 Anti-PD-L1 antibodies and uses therefor
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US Patent 8552156 Anti-TIM-3 antibody
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US Patent 8568728 Beta-glucuronide-linker drug conjugates
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US Patent 8580247 PS-1 antibodies in combination with a cytokine-secreting cell and methods of use thereof
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US Patent 8609089 Compositions of PD-1 antagonists and methods of use
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US Patent 8617546 Anticancer agent comprising anti-PD-1 antibody or anti-PD-L1 antibody
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US Patent 8647623 Method for treatment of blood tumor using anti-TIM-3 antibody
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US Patent 8685980 Pyrrolopyrimidine compounds and their uses
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US Patent 8697069 Methods related to TIM 3, a Th1-specific cell surface molecule, for activating antigen presenting cells
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US Patent 8709412 Modulation of TIM receptor activity in combination with cytoreductive therapy
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US Patent 8709416 Compositions of PD-1 antagonists and methods of use
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US Patent 8709429 Markers of acute myeloid leukemia stem cells
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US Patent 8715619 Compositions and methods for treating haematological proliferative disorders of myeloid origin
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US Patent 8728474 Immunopotentiative composition
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US Patent 8735551 Antibodies for epidermal growth factor receptor 3 (HER3)
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US Patent 8735553 Anti-PD1 antibodies and their use as therapeutics and diagnostics
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US Patent 8779105 Monoclonal antibodies to programmed death 1 (PD-1)
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US Patent 8779108 Targeted binding agents against B7-H1
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US Patent 8841418 Antibodies that specifically bind to TIM3
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US Patent 8900587 Antibodies to human programmed death receptor PD-1
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US Patent 8927697 PD-1 specific antibodies and uses thereof
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US Patent 8952136 Antibodies to human programmed death receptor PD-1
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US Patent 9045545 Precision medicine by targeting PD-L1 variants for treatment of cancer
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US Patent 9067999 Immunopotentiative composition
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US Patent 9073994 Immunopotentiative composition
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US Patent 9084776 Methods for treating cancer using anti-PD-1 antibodies
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US Patent 9102727 Human anti-PD-1 antibodies and uses therefor
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US Patent 9103832 Method for treatment of blood tumor using anti-TIM-3 antibody
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US Patent 9109034 Precision medicine by targeting PD-L1 variants for treatment of cancer
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US Patent 9132281 Focused radiation for augmenting immune-based therapies against neoplasms
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US Patent 9175082 Antigen binding proteins that bind PD-L1
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US Patent 9238646 N-(hetero)aryl, 2-(hetero)aryl-substituted acetamides for use as WNT signaling modulators
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US Patent 9333256 Methods related to TIM 3, a Th1-specific cell surface molecule, for activating antigen presenting cells
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US Patent 9358289 Methods for treating cancer using anti-PD-1 antibodies in combination with anti-CTLA-4 antibodies
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US Patent 9387247 Monoclonal antibodies to programmed death 1 (PD-1)
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US Patent 9409970 Polynucleotides encoding BSL2v2c2
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US Patent 9457080 Methods and compositions for the treatment of persistent infections and cancer by inhibiting the programmed cell death 1 (PD-1) pathway
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US Patent 9492539 Monoclonal antibodies to Programmed Death 1 (PD-1)
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US Patent 9492540 Methods for treating cancer using anti-PD-1 antibodies
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US Patent 9505839 Optimization of antibodies that bind lymphocyte activation gene-3 (LAG-3), and uses thereof
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US Patent 9605070 Antibody molecules to TIM-3 and uses thereof
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US Patent 9683048 Antibody molecules to PD-1 and uses thereof
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US Patent 9815898 Antibody molecules to PD-1 and uses thereof
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US Patent 9815901 Treatment of cancer using a CD123 chimeric antigen receptor
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US Patent 9834605 Antibodies to human programmed death receptor PD-1
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US Patent 9884913 Antibody molecules to TIM-3 and uses thereof
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US Patent 9908936 Antibody molecules to LAG-3 and uses thereof
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US Patent 9944645 Imidazotriazines and imidazopyrimidines as kinase inhibitors
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US Patent 9988452 Antibody molecules to PD-L1 and uses thereof
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US Patent 10251893 N-(hetero)aryl, 2-(hetero)aryl-substituted acetamides for use as Wnt signaling modulators
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US Patent 10344089 Human antibodies that bind lymphocyte activation gene-3 (LAG-3), and uses thereof
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US Patent 10472419 Antibody molecules to TIM-3 and uses thereof
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US Patent 10570204 Methods for treating hematologic cancers
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US Patent 10711060 Antibody molecules to LAG-3 and uses thereof
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US Patent 10752687 Antibody molecules to PD-1 and uses thereof
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US Patent 10851165 Antibody molecules to PD-L1 and methods of treating cancer
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US Patent 10981990 Antibody molecules to TIM-3 and uses thereof
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US Patent 11344620 Combination therapies
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Patent Primary Examiner
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Ilia I Ouspenski
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