Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Dale T. Umetsu0
Gordon Freeman0
Jennifer Jones McIntire0
Rosemarie Dekruyff0
Date of Patent
November 23, 2010
Patent Application Number
10663497
Date Filed
September 15, 2003
Patent Citations Received
Patent Primary Examiner
Patent abstract
A genetic locus and corresponding family of proteins associated with regulation of immune development, function, and cell survival are provided. The locus comprising the TIM family is genetically associated with immune dysfunction, including atopy, autoimmunity, inflammatory bowel disease, dysplasia, and susceptibility to blood-bourne infectious diseases. Polymorphisms in the human TIM-1 gene and exposure to Hepatitis A Virus (HAV) are shown to be associated with protection from the development of atopy.
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