Is a
Patent attributes
Patent Jurisdiction
Patent Number
Date of Patent
August 19, 2008
Patent Application Number
10416798
Date Filed
November 14, 2001
Patent Citations Received
Patent Primary Examiner
Patent abstract
The invention relates to BALB/c mice that are deficient in the programmed cell death-1 receptor (PD-1), a screening method for autoimmune disease medicine using these mice, an IgG self-reactive antibody that the mice produce, a protein that specifically reacts to the antibody and is produced in heart, and a diagnostic method for dilated cardiomyopathy using the protein. Because PD-1 deficient BALB/c mice spontaneously develop autoimmune disease, and specifically dilated cardiomyopathy, they are useful for screening for medicines against these diseases.
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