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US Patent 10550098 Pyridin-2(1H)-one quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors

Patent 10550098 was granted and assigned to FORMA Therapeutics on February, 2020 by the United States Patent and Trademark Office.

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Is a

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Patent attributes

Patent Applicant

FORMA Therapeutics

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Current Assignee

FORMA Therapeutics

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Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Zhongguo Wang0

Anna Ericsson0

David R. Lancia, Jr.0

Susan Ashwell0

Wei Lu0

Ann-Marie Campbell0

Gary Gustafson0

Jian Lin0

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Date of Patent

February 4, 2020

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Patent Application Number

162902400

Date Filed

March 1, 2019

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Patent Citations

US Patent 10294206 Fused-bicyclic aryl quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors

US Patent 10280150 Quinolinone pyrimidines compositions as mutant-isocitrate dehydrogenase inhibitors

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US Patent 10407419 Quinolinone five-membered heterocyclic compounds as mutant-isocitrate dehydrogenase inhibitors

US Patent 10414752 Pyridin-2(1H)-one quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors

US Patent 10005734 Pyridin-2(1H)-one quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors

US Patent 10253015 Pyridinyl quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors

US Patent 10266495 Phenyl quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors

Patent Citations Received

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US Patent 11498913 Pyridin-2(1H)-one quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors

US Patent 10807976 Quinolinone five-membered heterocyclic compounds as mutant-isocitrate dehydrogenase inhibitors

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US Patent 10889567 Pyridin-2(1H)-one quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors

US Patent 11576906 Inhibiting mutant IDH-1

US Patent 10959994 Solid forms of ((S)-5-((1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)amino)-1-methyl-6-oxo-1,6-dihydropyridine-2-carbonitrile

US Patent 11013733 Inhibiting mutant isocitrate dehydrogenase 1 (mlDH-1)

US Patent 11013734 Treating patients harboring an isocitrate dehydrogenase-1 (IDH-1) mutation

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Patent Primary Examiner

D Margaret M Seaman

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Patent abstract

The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula:

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