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US Patent 10435458 Antibody constant region variants with reduced Fcgammar binding

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Contents

Is a
Patent
Patent
0

Patent attributes

Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
0
Patent Number
104354580
Patent Inventor Names
Atsuhiko Maeda0
Futa Mimoto0
Taichi Kuramochi0
Tomoyuki Igawa0
Date of Patent
October 8, 2019
0
Patent Application Number
135820730
Date Filed
March 4, 2011
0
Patent Citations
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US Patent 10150808 Modified antibody constant regions
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US Patent 10066018 Antibody constant region variant
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US Patent 10253091 Antibody constant region variant
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US Patent 10011858 Methods for producing polypeptides by regulating polypeptide association
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Patent Citations Received
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US Patent 12122840 Method of modifying isoelectric point of antibody via amino acid substitution in CDR
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US Patent 11505605 T cell-redirected antigen-binding molecule for cells having immunosuppression function
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US Patent 11072666 Cell injury inducing therapeutic drug for use in cancer therapy
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US Patent 11248053 Method of modifying isoelectric point of antibody via amino acid substitution in CDR
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US Patent 11649262 Method for promoting efficiency of purification of Fc region-containing polypeptide
0
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US Patent 11660340 Combination therapy using T cell redirection antigen binding molecule against cell having immunosuppressing function
0
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US Patent 11332533 Modified antibody constant region
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US Patent 12116414 Method of modifying isoelectric point of antibody via amino acid substitution in CDR
0
...
Patent Primary Examiner
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Michael Allen
0
Patent abstract

The present inventors carried out dedicated research to generate antibody constant regions with reduced Fcγ receptor-binding activity by altering amino acid sequences in the antibody constant region. As a result, the present inventors successfully identified novel constant region sequences with reduced Fcγ receptor-binding activity compared to conventional antibody constant regions.

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