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US Patent 10179911 Negative selection and stringency modulation in continuous evolution systems

Patent 10179911 was granted and assigned to President and Fellows of Harvard College on January, 2019 by the United States Patent and Trademark Office.

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US Patent 12084663 Incorporation of unnatural amino acids into proteins using base editing
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US Patent 12060553 Evolution of BoNT peptidases
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US Patent 12006520 Evaluation and improvement of nuclease cleavage specificity
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US Patent 11999947 Adenosine nucleobase editors and uses thereof
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US Patent 11932884 High efficiency base editors comprising Gam
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US Patent 11920181 Nuclease profiling system
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US Patent 11913044 Evolution of cytidine deaminases
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US Patent 11913040 Evolution of TALENs
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US Patent 11905623 Evolution of site-specific recombinases
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Patent abstract

Strategies, systems, methods, reagents, and kits for phage-assisted continuous evolution are provided herein. These include strategies, systems, methods, reagents, and kits allowing for stringency modulation to evolve weakly active or inactive biomolecule variants, negative selection of undesired properties, and/or positive selection of desired properties.

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Patent Inventor Names
Ahmed Hussein Badran0
David R. Liu0
Jacob Charles Carlson0
Kevin Michael Esvelt0
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US Patent 11760986 Evolution of proteases
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US Patent 11702651 Adenosine nucleobase editors and uses thereof
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US Patent 11661590 Programmable CAS9-recombinase fusion proteins and uses thereof
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US Patent 11643652 Methods and compositions for prime editing nucleotide sequences
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US Patent 11524983 Evolution of
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