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Cortexyme

Cortexyme

Cortexyme is a biotechnology company with a focus on developing therapeutics for Alzheimer's disease and other neurodegenerative diseases. It was founded in 2012 and is located in San Francisco, California.

OverviewStructured DataIssuesContributors

Contents

ProductTimelineTable: Funding RoundsTable: ProductsTable: AcquisitionsTable: SBIR/STTR AwardsTable: PatentsTable: Further ResourcesReferences
cortexyme.com
Is a
Organization
Organization
Company
Company

Company attributes

Industry
‌
Neurodegenerative Disease
Loading...
Healthcare
Healthcare
Pharmaceutical industry
Pharmaceutical industry
Biomedical engineering
Biomedical engineering
Technology
Technology
Neuroscience
Neuroscience
Consumer biotechnology
Consumer biotechnology
...
Location
South San Francisco, California
South San Francisco, California
California
California
United States
United States
San Francisco
San Francisco
B2X
B2B
B2B
CEO
‌
Casey Lynch
Founder
‌
Kristen Gafric
‌
Steve Dominy
‌
Casey Lynch
Pitchbook URL
pitchbook.com/profiles.../63821-35
Legal Name
Cortexyme, Inc.
Number of Employees (Ranges)
11 – 50
Email Address
info@cortexyme.com
Phone Number
+14159105717
Full Address
269 East Grand Avenue Verily Campus South San Francisco, CA 94080 United States
CIK Number
1,662,7749
Place of Incorporation
Delaware
Delaware
9
Investors
Dolby Family Ventures
Dolby Family Ventures
Verily
Verily
‌
RSL Investments
EPIQ Capital Group
EPIQ Capital Group
Vulcan Capital
Vulcan Capital
Takeda Ventures
Takeda Ventures
Breakout Ventures
Breakout Ventures
Sequoia Capital
Sequoia Capital
...
DUNS Number
0791786848
Founded Date
2012
10
Total Funding Amount (USD)
278,000,000
Latest Funding Round Date
February 5, 2020
Competitors
Aquinox Pharmaceuticals
Aquinox Pharmaceuticals
‌
Cerecor
Soligenix
Soligenix
‌
KBP BioSciences
Biogen
Biogen
Trevena
Trevena
Alector
Alector
Otonomy
Otonomy
...
Business Model
Licensing
Stock Symbol
CRTX12
Exchange
Nasdaq
Nasdaq
12
Board of Directors
‌
Una Ryan
7
‌
Dirk Thye
7
‌
Philip Low
7
Latest Funding Type
Private equity
Private equity
CAGE Code
71EX08
Patents Assigned (Count)
1
Country
United States
United States

Other attributes

Company Operating Status
Active
Latest Funding Round Amount (USD)
125,000,000
SIC Code
2,8369
Ticker Symbol
CRTX

About

Cortexyme is a San Francisco-based biotechnology company focusing on developing therapies and treatments for degenerative diseases, such as Alzheimer's. The company is expanding its therapeutics to target an undisclosed pathogen that's tied to neurodegeneration.

Product

The company's lead therapeutic candidate is atuzaginstat (COR388). As of September 2020, the therapeutic is in Phase 2/3 of clinical trials with patients with mild to moderate Alzheimer's disease. The company's goal with this therapy is to target a pathogen in the brain that has shown to cause neurodegenerative conditions in animal models.

Cortexyme is conducting its GAIN trial with COR388, which is a novel virulence factor inhibitor targeting gingipains from P. gingivalis that have been found in the brain of Alzheimer's patients. The therapeutic is starting to show to block neuroinflammation and neurodegeneration in mice. The trial has over 500 participants and commenced in 2019. Results from the trial are expected to be complete by the end of 2021.

Timeline

No Timeline data yet.

Funding Rounds

Products

Acquisitions

SBIR/STTR Awards

Patents

Further Resources

Title
Author
Link
Type
Date

Cortexyme Announces Gain Trial in Alzheimer's Disease Has Reached Enrollment Milestone of 300 Patients

https://www.businesswire.com/news/home/20200316005315/en/Cortexyme-Announces-Gain-Trial-Alzheimer%E2%80%99s-Disease-Reached

Web

March 16, 2020

Cortexyme Completes $76 Million Series B Financing and Provides Update on Clinical Development Progress

Business Wire

https://www.businesswire.com/news/home/20180531005335/en/Cortexyme-Completes-76-Million-Series-Financing-Update

News article

Cortexyme Gain Trial Video

Gain Trial

https://vimeo.com/337325868

Web

May 20, 2019

References

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