SBIR/STTR Award attributes
Abstract Deep brain stimulationDBSwith implantable electrodes has been used for reduction of ethanol abuse and drug seeking behaviors in EuropeThe use of such deep brain stimulation procedures has been problematic because of concerns about invasiveness of the procedureApplicant has developed a new noninvasive method of transporting magnetic particles directly to target sites within the brainWe propose to use this method to place magnetic particles in brain locations where DBS studies have shown reductions in drug seeking behaviorOnce placedthe magnetic particles can be activated through external application of magnetic fields to stimulate neurons mechanicallyWhen translated into clinical usemagnetic activation could be performed with a wearable deviceas has been done for other neurological conditionsmigraineepilepsyThe particles are designed to degrade over a pre selected time intervale gsix monthsIn this proposalwe will demonstrate the short term safety and efficacy of the construct in an rodent model of opiate relapse after a period of abstinenceEfficacy will be measured by quantifying reinstatement of drug seeking behaviorThe results of this collaborative work will lay the foundation for Phase II studieswhich will provide information needed for human trials Summary Deep brain stimulation with implantable electrodes has been used for reduction of ethanol abuse and drug seeking behaviors in EuropeThe use of such deep brain stimulation procedures has been problematic because of concerns about invasiveness of the procedureCompany proposes to develop a noninvasive replacement for electrodebased deep brain stimulation
