Patent 9848587 was granted and assigned to Regeneron Pharmaceuticals on December, 2017 by the United States Patent and Trademark Office.
The invention provides genetically modified non-human animals that express chimeric human/non-human T cell co-receptor polypeptides (e.g., CD4, CD8α, CD8β), as well as embryos, cells, and tissues comprising the same. Also provided are constructs for making said genetically modified animals and methods of making the same.