Is a
Patent attributes
Patent Jurisdiction
Patent Number
Date of Patent
September 19, 2017
Patent Application Number
14680836
Date Filed
April 7, 2015
Patent Citations Received
Patent Primary Examiner
Patent abstract
An optimized coding sequence of human blood clotting factor eight (VIII) and a promoter may be used in vectors, such as rAAV, for introduction of factor VIII, and/or other blood clotting factors and transgenes. Exemplary of these factors and transgenes are alpha-1-antitrypsin, as well as those involved in the coagulation cascade, hepatocye biology, lysosomal storage, urea cycle disorders, and lipid storage diseases. Cells, vectors, proteins, and glycoproteins produced by cells transformed by the vectors and sequence, may be used in treatment.
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