Patent 9175289 was granted and assigned to Rxi Pharmaceuticals Corporation on November, 2015 by the United States Patent and Trademark Office.
The present invention relates to RNAi constructs with minimal double-stranded regions, and their use in gene silencing. RNAi constructs associated with the invention include a double stranded region of 8-14 nucleotides and a variety of chemical modifications, and are highly effective in gene silencing.