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Patent attributes
Patent Jurisdiction
Patent Number
Date of Patent
October 27, 2015
Patent Application Number
13521448
Date Filed
January 12, 2011
Patent Citations Received
...
Patent Primary Examiner
Patent abstract
This invention relates to modified parvovirus inverted terminal repeats (ITRs) that do not functionally interact with wild-type large Rep proteins, synthetic Rep proteins that functionally interact with the modified ITRs, and methods of using the same for delivery of nucleic acids to a cell or a subject. The modifications provide a novel Rep-ITR interaction that limits vector mobilization, increasing the safety of viral vectors.
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