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US Patent 12104165 Adeno-associated virus with engineered capsid

Patent 12104165 was granted and assigned to Tenaya Therapeutics on October, 2024 by the United States Patent and Trademark Office.

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Patent
Patent
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Patent attributes

Patent Applicant
Tenaya Therapeutics
Tenaya Therapeutics
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Current Assignee
Tenaya Therapeutics
Tenaya Therapeutics
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
121041650
Patent Inventor Names
Christopher A. Reid0
Date of Patent
October 1, 2024
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Patent Application Number
184936630
Date Filed
October 24, 2023
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Patent Citations
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US Patent 7070994 Packaging cells
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US Patent 7091029 High titer recombinant AAV production
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US Patent 7105345 Adeno-associated virus serotype 1 nucleic acid sequences, vectors and host cells containing same
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US Patent 7198951 Adeno-associated virus (AAV) serotype 9 sequences, vectors containing same, and uses therefor
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US Patent 7259151 AAV virions with decreased immunoreactivity and uses therefor
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US Patent 7718424 AAV4 vector and uses thereof
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US Patent 7790449 Adeno-associated virus (AAV) serotype 8 sequences, vectors containing the same, and uses therefor
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US Patent 7867484 Heparin and heparan sulfate binding chimeric vectors
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...
Patent Primary Examiner
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Maria Marvich
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Patent abstract

The present disclosure provides recombinant adeno-associated virus (rAAV) virions with an engineered capsid protein identified using a high-throughput sequencing screen or rational design. In particular, the disclosure provides AAV5 virions and capsid proteins with increased transduction efficiency in cardiac cells, increased cell-type selectivity, and/or other desirable properties.

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