Patent 9113616 was granted and assigned to Regeneron Pharmaceuticals on August, 2015 by the United States Patent and Trademark Office.
The invention provides a genetically modified non-human animal that comprises in its genome unrearranged T cell receptor variable gene loci, as well as embryos, cells, and tissues comprising the same. Also provided are constructs for making said genetically modified non-human animal and methods of making the same. Various methods of using the genetically modified non-human animal are also provided.