Is a
Patent attributes
Patent Applicant
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Naxin Tu0
Vera Voronina0
Andrew J. Murphy0
Cagan Gurer0
Lynn MacDonald0
Sean Stevens0
Date of Patent
June 2, 2015
0Patent Application Number
137939350
Date Filed
March 11, 2013
0Patent Citations Received
Patent Primary Examiner
Patent abstract
The invention provides genetically modified non-human animals that express a humanized MHC II protein (humanized MHC II α and β polypeptides), as well as embryos, cells, and tissues comprising the humanized MHC II protein. Also provided are constructs for and methods of making the genetically modified non-human animals. Methods of using the genetically modified non-human animals to study various aspects of the human immune system are provided.
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