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US Patent 9023649 RNA-guided human genome engineering

Patent 9023649 was granted and assigned to President and Fellows of Harvard College on May, 2015 by the United States Patent and Trademark Office.

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Contents

Is a
Patent
Patent

Patent attributes

Patent Applicant
‌
President and Fellows of Harvard College
Current Assignee
‌
President and Fellows of Harvard College
Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
Patent Number
9023649
Date of Patent
May 5, 2015
Patent Application Number
14319100
Date Filed
June 30, 2014
Patent Citations Received
‌
US Patent 12123015 Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
0
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US Patent 12084663 Incorporation of unnatural amino acids into proteins using base editing
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US Patent 12084675 Using programmable DNA binding proteins to enhance targeted genome modification
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US Patent 12110545 Methods of assessing nuclease cleavage
0
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US Patent 11661590 Programmable CAS9-recombinase fusion proteins and uses thereof
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US Patent 11667911 Use of exonucleases to improve CRISPR/CAS-mediated genome editing
0
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US Patent 11674159 Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
0
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US Patent 11680259 Recombinant type I CRISPR-CAS system
0
...
Patent Primary Examiner
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Misook Yu
Patent abstract

A method of altering a eukaryotic cell is provided including transfecting the eukaryotic cell with a nucleic acid encoding RNA complementary to genomic DNA of the eukaryotic cell, transfecting the eukaryotic cell with a nucleic acid encoding an enzyme that interacts with the RNA and cleaves the genomic DNA in a site specific manner, wherein the cell expresses the RNA and the enzyme, the RNA binds to complementary genomic DNA and the enzyme cleaves the genomic DNA in a site specific manner.

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