US Patent 8975389 Nucleic acid chemical modifications
Patent 8975389 was granted and assigned to Alnylam Pharmaceuticals on March, 2015 by the United States Patent and Trademark Office.
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Patent abstract
The present invention provides nucleosides of formula (1) and oligonucleotides comprising at least one nucleoside of formula (2): Another aspect of the invention relates to a method of inhibiting the expression of a gene in cell, the method comprising (a) contacting an oligonucleotide of the invention with the cell; and (b) maintaining the cell from step (a) for a time sufficient to obtain degradation of the mRNA of the target gene.
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Patent Inventor Names
Alexander V. Kelin0
Kallanthottathil G. Rajeev0
Muthiah Manoharan0
Shigeo Matsuda0
Sudhakar Rao Takkellapati0
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US Patent 08975389 Nucleic acid chemical modifications US Patent 8975389 Nucleic acid chemical modifications
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Patent Number
089753890
Patent Number
89753890
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Current Assignee
Patent Jurisdiction
Patent Number
089753890
Date of Patent
March 10, 2015
0Patent Application Number
132039270
Date Filed
March 2, 2010
0Official Website
Patent Primary Examiner
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US Patent 08975389 Nucleic acid chemical modifications
Infobox
Is a
Current assignee
Patent jurisdiction
Patent number
08975389
Date of patent
March 10, 2015
Patent application number
13203927
Date Filed
March 2, 2010
Patent primary examiner
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