Is a
Patent attributes
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Alexander V. Kelin0
Kallanthottathil G. Rajeev0
Muthiah Manoharan0
Shigeo Matsuda0
Sudhakar Rao Takkellapati0
Date of Patent
March 10, 2015
0Patent Application Number
132039270
Date Filed
March 2, 2010
0Patent Citations Received
Patent Primary Examiner
Patent abstract
The present invention provides nucleosides of formula (1) and oligonucleotides comprising at least one nucleoside of formula (2): Another aspect of the invention relates to a method of inhibiting the expression of a gene in cell, the method comprising (a) contacting an oligonucleotide of the invention with the cell; and (b) maintaining the cell from step (a) for a time sufficient to obtain degradation of the mRNA of the target gene.
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