Is a
Patent attributes
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Roger Hart0
Ronald Nixon Keener, III0
Joseph Edward Shultz0
Date of Patent
February 10, 2015
0Patent Application Number
128200870
Date Filed
June 21, 2010
0Patent Citations Received
Patent Primary Examiner
Patent abstract
A method of refolding proteins expressed in non-mammalian cells present in concentrations of 2.0 g/L or higher is disclosed. The method comprises identifying the thiol pair ratio and the redox buffer strength to achieve conditions under which efficient folding at concentrations of 2.0 g/L or higher is achieved and can be employed over a range of volumes, including commercial scale.
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