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US Patent 8680258 Use of microRNAs to control virus helper nucleic acids

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Patent
Patent

Patent attributes

Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
Patent Number
8680258
Patent Inventor Names
Jonathan F. Smith3
Kurt I. Kamrud3
Vernon McNeil Coffield3
Date of Patent
March 25, 2014
Patent Application Number
13132035
Date Filed
November 25, 2009
Patent Citations Received
‌
US Patent 12134777 Alphavirus replicon vector and immunotherapy by administering same
1
‌
US Patent 11771747 Multiepitope vaccine cassettes
‌
US Patent 12109257 Alphavirus neoantigen vectors
2
Patent Primary Examiner
‌
Kimberly Chong
Patent abstract

Provided herein are helper nucleic acids comprising at least one microRNA target sequence of an endogenous, cellular microRNA and a nucleic acid encoding a viral protein, wherein the microRNA target sequence is located in the untranslated or translated region of the nucleic acid encoding the viral protein. Also provided are vector systems, compositions and cells comprising the provided helper nucleic acids and a vector or replicon. Methods of making virus-like replicon particles and populations of virus-like replicon particles (VRP) are also provided.

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