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US Patent 12109257 Alphavirus neoantigen vectors

Patent 12109257 was granted and assigned to Gritstone Bio on October, 2024 by the United States Patent and Trademark Office.

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Is a
Patent
Patent
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Patent attributes

Patent Applicant
Gritstone Bio
Gritstone Bio
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Current Assignee
Gritstone Bio
Gritstone Bio
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
121092570
Patent Inventor Names
Leonid Gitlin0
Karin Jooss0
Wade Blair0
Ciaran Daniel Scallan0
Amy Rachel Rappaport0
Date of Patent
October 8, 2024
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Patent Application Number
180458120
Date Filed
October 11, 2022
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Patent Citations
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US Patent 7344872 Method for rapid screening of bacterial transformants and novel simian adenovirus proteins
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US Patent 7468181 Means and methods for the production of adenovirus vectors
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US Patent 7507803 Optimized multi-epitope constructs and uses thereof
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US Patent 7531180 Chimeric alphavirus replicon particles
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US Patent 7541038 Fusogenic, self-propagating blebs as immunogenic compositions
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US Patent 7557200 Superior molecular vaccine based on self-replicating RNA, suicidal DNA or naked DNA vector, that links antigen with polypeptide that promotes antigen presentation
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US Patent 7572453 Chimeric alphavirus replicon particles
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US Patent 7572628 Eukaryotic layered vector initiation systems
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...
Patent Primary Examiner
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Stacy B. Chen
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Patent abstract

Disclosed herein are alphavirus vectors that include neoantigen-encoding nucleic acid sequences derived from a tumor of a subject. Also disclosed are nucleotides, cells, and methods associated with the vectors including their use as vaccines.

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