US Patent 8632989 Mutant insulin degrading enzyme and methods of use
Patent 8632989 was granted and assigned to University of Kentucky on January, 2014 by the United States Patent and Trademark Office.
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Patent abstract
In one aspect, the present invention provides an isolated mutant insulin degrading enzyme (IDE) having an amino acid sequence that is at least 90% identical to SEQ ID NO:1 over its entire length and comprises at least one amino acid substitution at any of amino acid residues 332, 339, 341, 359, 360, 361, 374, 429, 609, 898, 899 or 901 of the sequence. The mutant IDE has a differential activity relative to that of wild-type IDE. Also provided is a polynucleotide encoding the polypeptide of the invention.
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Patent Inventor Names
David W. Rodgers0
Eun Suk Song0
Louis B. Hersh0
Nicholas Noinaj0
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US Patent 08632989 Mutant insulin degrading enzyme and methods of use US Patent 8632989 Mutant insulin degrading enzyme and methods of use
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Patent Number
08632989
Patent Number
8632989
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US Patent 08632989 Mutant insulin degrading enzyme and methods of use
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Is a
Current assignee
Patent jurisdiction
Patent number
08632989
Date of patent
January 21, 2014
Patent application number
13484573
Date Filed
May 31, 2012
Patent primary examiner
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