Is a
Patent attributes
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Nicholas Noinaj0
David W. Rodgers0
Eun Suk Song0
Louis B. Hersh0
Date of Patent
January 21, 2014
Patent Application Number
13484573
Date Filed
May 31, 2012
Patent Citations Received
Patent Primary Examiner
Patent abstract
In one aspect, the present invention provides an isolated mutant insulin degrading enzyme (IDE) having an amino acid sequence that is at least 90% identical to SEQ ID NO:1 over its entire length and comprises at least one amino acid substitution at any of amino acid residues 332, 339, 341, 359, 360, 361, 374, 429, 609, 898, 899 or 901 of the sequence. The mutant IDE has a differential activity relative to that of wild-type IDE. Also provided is a polynucleotide encoding the polypeptide of the invention.
Timeline
No Timeline data yet.
Further Resources
No Further Resources data yet.
