Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Lin Yang0
Xiao Xiao0
Date of Patent
January 21, 2014
0Patent Application Number
129904600
Date Filed
April 29, 2009
0Patent Citations Received
...
Patent Primary Examiner
Patent abstract
The present invention provides methods of achieving directed evolution of viruses by in vivo screening or “panning” to identify viruses comprising scrambled AAV capsids having characteristics of interest, e.g., tropism profile and/or neutralization profile (e.g., ability to evade neutralizing antibodies). The invention also provides scrambled AAV capsids and virus particles comprising the same.
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