US Patent 7700555 Methods of treating diabetes
Patent 7700555 was granted and assigned to Joslin Diabetes Center (company) on April, 2010 by the United States Patent and Trademark Office.
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The invention provides methods of screening for compounds that increase levels or activity of Aryl hydrocarbon Nuclear Receptor Translocator (ARNT) and/or Hypoxia Inducible Factor 1α (HIF1α), for the treatment and prevention of diabetes-related disorders, including type 1 and type 2 diabetes mellitus, impaired glucose tolerance, insulin resistance and beta cell dysfunction; compounds identified by said screening methods; and methods of using said compounds. Also included are methods for treating or preventing diabetes-related diseases using ARNT and/or HIF1α polypeptides and polynucleotides, and for using information regarding the expression, level or activity of ARNT and/or HIF1α in predictive medicine, e.g., diagnostic assays, prognostic assays, monitoring clinical trials, and pharmacogenetics.
US Patent 07700555 Methods of treating diabetes US Patent 7700555 Methods of treating diabetes
US Patent 07700555 Methods of treating diabetes
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