US Patent 7700555 Methods of treating diabetes

Patent 7700555 was granted and assigned to Joslin Diabetes Center (company) on April, 2010 by the United States Patent and Trademark Office.

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Is a

Patent

Patent attributes

Current Assignee

Joslin Diabetes Center (company)

Patent Jurisdiction

United States Patent and Trademark Office

Patent Number

77005550

Patent Inventor Names

Jenny Gunton0

C. Ronald Kahn0

Date of Patent

April 20, 2010

Patent Application Number

116535940

Date Filed

January 16, 2007

Patent Primary Examiner

‌

Manjunath N. Rao

Patent abstract

The invention provides methods of screening for compounds that increase levels or activity of Aryl hydrocarbon Nuclear Receptor Translocator (ARNT) and/or Hypoxia Inducible Factor 1α (HIF1α), for the treatment and prevention of diabetes-related disorders, including type 1 and type 2 diabetes mellitus, impaired glucose tolerance, insulin resistance and beta cell dysfunction; compounds identified by said screening methods; and methods of using said compounds. Also included are methods for treating or preventing diabetes-related diseases using ARNT and/or HIF1α polypeptides and polynucleotides, and for using information regarding the expression, level or activity of ARNT and/or HIF1α in predictive medicine, e.g., diagnostic assays, prognostic assays, monitoring clinical trials, and pharmacogenetics.