Is a
Patent attributes
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Joseph D. Gold0
Melissa K. Carpenter0
Chunhui Xu0
Margaret S. Inokuma0
Date of Patent
August 19, 2008
0Patent Application Number
109489560
Date Filed
September 24, 2004
0Patent Citations Received
Patent Primary Examiner
Patent abstract
This disclosure provides a system for obtaining genetically altered primate pluripotent stem (pPS) cells. The role of the feeder cells is replaced by supporting the culture on an extracellular matrix, and culturing the cells in a conditioned medium. The cells can be genetically altered with a viral vector or DNA/lipid complex, and then selected for successful transfection by drug-resistant phenotype in the transfected cells. The system allows for bulk proliferation of genetically altered pPS cells as important products for use in human therapy or drug screening.
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