US Patent 7371728 Prostate-specific antigen probes for optical imaging

Patent 7371728 was granted and assigned to Kaohsiung Medical University on May, 2008 by the United States Patent and Trademark Office.

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Patent Inventor Names

Gin-Chung Liu0

Jui-Sheng Hsu0

Wei-Hsan Chao0

Yun-Ming Wang0

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Patent abstract

This invention provides a novel probe, which contains a prostate peptide substrate. The probe can be used as a prostate diagnostic agent for optical imaging. An 11 amino acid peptide substrate is synthesized for specific prostate-specific antigen (PSA). This protected graft copolymer (PGC) consists of a poly-L-lysine (PL) backbone and methoxypoly(ethylene glycol) (MPEG). Two terminals of peptide substrate are bound to poly-L-lysine and Cy5.5 fluorochrome. This probe will be used as a NIR (near-infrared fluorescence) probe for optical imaging.

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Official Website

https://pdfpiw.uspto.gov/.piw?Docid=073717280

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