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US Patent 7371728 Prostate-specific antigen probes for optical imaging

Patent 7371728 was granted and assigned to Kaohsiung Medical University on May, 2008 by the United States Patent and Trademark Office.

Overview Structured Data Issues Contributors

Is a

Patent

Patent attributes

Current Assignee

Kaohsiung Medical University

Patent Jurisdiction

United States Patent and Trademark Office

Patent Number

73717280

Patent Inventor Names

Wei-Hsan Chao0

Yun-Ming Wang0

Gin-Chung Liu0

Jui-Sheng Hsu0

Date of Patent

May 13, 2008

Patent Application Number

113250740

Date Filed

January 4, 2006

Patent Primary Examiner

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Andrew D. Kosar

Patent abstract

This invention provides a novel probe, which contains a prostate peptide substrate. The probe can be used as a prostate diagnostic agent for optical imaging. An 11 amino acid peptide substrate is synthesized for specific prostate-specific antigen (PSA). This protected graft copolymer (PGC) consists of a poly-L-lysine (PL) backbone and methoxypoly(ethylene glycol) (MPEG). Two terminals of peptide substrate are bound to poly-L-lysine and Cy5.5 fluorochrome. This probe will be used as a NIR (near-infrared fluorescence) probe for optical imaging.