US Patent 7335763 Herpesvirus ribozymes and vectors

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Patent Inventor Names

Alfred Samuel Lewin0

David Clair Bloom0

Gregory Scott Schultz0

Jia Liu0

Sonal Sanjeen Tuli0

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Patent abstract

Hammerhead ribozymes that target components critical to HSV replication (ICP4, UL20, UL30, and UL54) were synthesized and shown to efficiently cleave target RNA encoding a portion of these components in in vitro assays. Several cloned cell lines stably expressing these ribozymes were established. HSV-mediated plaque formation was dramatically reduced in cells stably transfected with an anti-HSV ribozyme compared to non-transfected cells.

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https://pdfpiw.uspto.gov/.piw?Docid=07335763

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