Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Alfred Samuel Lewin0
Gregory Scott Schultz0
Jia Liu0
Sonal Sanjeen Tuli0
David Clair Bloom0
Date of Patent
February 26, 2008
Patent Application Number
10808042
Date Filed
March 24, 2004
Patent Primary Examiner
Patent abstract
Hammerhead ribozymes that target components critical to HSV replication (ICP4, UL20, UL30, and UL54) were synthesized and shown to efficiently cleave target RNA encoding a portion of these components in in vitro assays. Several cloned cell lines stably expressing these ribozymes were established. HSV-mediated plaque formation was dramatically reduced in cells stably transfected with an anti-HSV ribozyme compared to non-transfected cells.
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