US Patent 6867284 Peptide inhibitors of hepatitis C virus NS3 protease
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Patent abstract
Fluorinated oligopeptides, especially those having 4,4-difluoro-2-amino butyric acid at the C terminus, may be effective inhibitors of hepatitis C virus NS3 protease. Examples of hexapeptides of the invention, optimized for binding in the S1 specificity pocket of the enzyme, may display IC50s at the sub-micromolar level. Embodiments of tripeptides of the invention, having a keto-acid group at the C-terminus are, likewise, potent inhibitors of NS3 protease.
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Patent Inventor Names
Antonella Marchetti0
Frank Narjes0
Jesus Ontoria0
Konrad Forster Koehler0
Marco Poma0
Victor Matassa0
Date of Patent
March 15, 2005
0Patent Application Number
097192610
Date Filed
June 9, 1999
0Patent Primary Examiner
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US Patent 6867284 Peptide inhibitors of hepatitis C virus NS3 protease
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