Is a
Patent attributes
Patent Applicant
0
Patent Jurisdiction
Patent Number
Patent Inventor Names
Frank Narjes0
Antonella Marchetti0
Jesus Ontoria0
Konrad Forster Koehler0
Marco Poma0
Victor Matassa0
Date of Patent
March 15, 2005
0Patent Application Number
097192610
Date Filed
June 9, 1999
0Patent Citations Received
Patent Primary Examiner
Patent abstract
Fluorinated oligopeptides, especially those having 4,4-difluoro-2-amino butyric acid at the C terminus, may be effective inhibitors of hepatitis C virus NS3 protease. Examples of hexapeptides of the invention, optimized for binding in the S1 specificity pocket of the enzyme, may display IC50s at the sub-micromolar level. Embodiments of tripeptides of the invention, having a keto-acid group at the C-terminus are, likewise, potent inhibitors of NS3 protease.
Timeline
No Timeline data yet.
Further Resources
No Further Resources data yet.