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US Patent 12121569 Methods and compositions for CNS delivery of iduronate-2-sulfatase

Patent 12121569 was granted and assigned to Takeda Pharmaceutical Company on October, 2024 by the United States Patent and Trademark Office.

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Patent abstract

The present invention provides, among other things, compositions and methods for CNS delivery of lysosomal enzymes for effective treatment of lysosomal storage diseases. In some embodiments, the present invention includes a stable formulation for direct CNS intrathecal administration comprising an iduronate-2-sulfatase (I2S) protein, salt, and a polysorbate surfactant for the treatment of Hunters Syndrome.

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