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US Patent 10456454 CNS delivery of therapeutic agents

Patent 10456454 was granted and assigned to Shire (pharmaceutical company) on October, 2019 by the United States Patent and Trademark Office.

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Is a
Patent
Patent

Patent attributes

Patent Applicant
Shire (pharmaceutical company)
Shire (pharmaceutical company)
Current Assignee
Shire (pharmaceutical company)
Shire (pharmaceutical company)
Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
Patent Number
10456454
Date of Patent
October 29, 2019
Patent Application Number
15016141
Date Filed
February 4, 2016
Patent Citations Received
‌
US Patent 12121569 Methods and compositions for CNS delivery of iduronate-2-sulfatase
0
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US Patent 11052135 Methods and compositions for treating hunter syndrome
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US Patent 11471516 CNS delivery of therapeutic agents
Patent Primary Examiner
‌
Lisa J Hobbs
Patent abstract

The present invention provides an effective and less invasive approach for direct delivery of therapeutic agents to the central nervous system (CNS). In some embodiments, the present invention provides methods including a step of administering intrathecally to a subject suffering from or susceptible to a lysosomal storage disease associated with reduced level or activity of a lysosomal enzyme, a composition comprising a replacement enzyme for the lysosomal enzyme.

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