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US Patent 12110491 Selective reduction of allelic variants

Patent 12110491 was granted and assigned to Ionis Pharmaceuticals on October, 2024 by the United States Patent and Trademark Office.

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 US Patent 12110491 Selective reduction of allelic variants

Article

Patent abstract

Disclosed herein are antisense compounds and methods for selectively reducing expression of an allelic variant of a gene containing a single nucleotide polymorphism (SNP). Such methods, compounds, and composition are useful to treat, prevent, or ameliorate diseases, including neurodegenerative diseases, such as Huntington's Disease (HD).

Infobox
Is a
Patent
Patent
0
Patent Applicant
Ionis Pharmaceuticals
Ionis Pharmaceuticals
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Current Assignee
Ionis Pharmaceuticals
Ionis Pharmaceuticals
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
121104910
Patent Inventor Names
C. Frank Bennett0
Eric E. Swayze0
Sarah Greenlee0
Susan M. Freier0
Date of Patent
October 8, 2024
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Patent Application Number
175778320
Date Filed
January 18, 2022
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Patent Citations
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US Patent 11149264 Modified compounds and uses thereof
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US Patent 8093222 Methods for treating hypercholesterolemia
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US Patent 8957040 Selective reduction of allelic variants
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US Patent 9006198 Selective reduction of allelic variants
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US Patent 9688985 MicroRNA compounds and methods for modulating miR-21 activity
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US Patent 9695418 Oligomeric compounds comprising bicyclic nucleosides and uses thereof
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US Patent 9752142 Gapped oligomeric compounds comprising 5′-modified deoxyribonucleosides in the gap and uses thereof
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US Patent 9914922 Oligomeric compounds comprising bicyclic nucleotides and uses thereof
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US Patent 10017764 Oligomeric compounds comprising bicyclic nucleotides and uses thereof
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US Patent 10202599 Selective antisense compounds and uses thereof
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US Patent 10260069 Selective antisense compounds and uses thereof
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US Patent 10337007 Oligomeric compounds comprising bicyclic nucleotides and uses thereof
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US Patent 11236335 Selective antisense compounds and uses thereof
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US Patent 11332733 Modified compounds and uses thereof
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US Patent 7034133 Oligonucleotide analogues
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US Patent 7053207 L-ribo-LNA analogues
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Patent Primary Examiner
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Ekaterina Poliakova-Georgantas
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