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US Patent 12076366 Therapeutic vitamin D conjugates

Patent 12076366 was granted and assigned to Extend Biosciences on September, 2024 by the United States Patent and Trademark Office.

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Is a
Patent
Patent
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Patent attributes

Patent Applicant
Extend Biosciences
Extend Biosciences
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Current Assignee
Extend Biosciences
Extend Biosciences
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
120763660
Patent Inventor Names
Howard P. Sard0
Daniel B. Hall0
Vishnumurthy Hegde0
Laura M. Hales0
Tarik Soliman0
Christopher So0
Date of Patent
September 3, 2024
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Patent Application Number
169206520
Date Filed
July 3, 2020
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Patent Citations
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US Patent 7045318 Recombinant fusion proteins to growth hormone and serum albumin
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US Patent 7049285 Biocompatible polymers including peptide spacer
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US Patent 7057012 PTH functional domain conjugate peptides, derivatives thereof and novel tethered ligand-receptor molecules
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US Patent 7078496 Thioester-terminated water soluble polymers and method of modifying the N-terminus of a polypeptide therewith
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US Patent 7141547 Albumin fusion proteins comprising GLP-1 polypeptides
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US Patent 7176278 Modified transferrin fusion proteins
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US Patent 7186797 Polypeptide conjugates with extended circulating half-lives
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US Patent 7217689 Glycosylation analogs of erythropoietin
0
...
Patent Primary Examiner
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Julie Ha
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Patent abstract

The invention provides non-hormonal vitamin D conjugated to apelin proteins that result in increased absorption, bioavailability or circulating half-life when compared to non-conjugated forms. In some embodiments, the vitamin D targeting groups are coupled to the apelin proteins via the third carbon on the vitamin D backbone.

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