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US Patent 12059413 Methods of inhibiting viruses using compositions targeting TSG101-ubiquitin interaction

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 US Patent 12059413 Methods of inhibiting viruses using compositions targeting TSG101-ubiquitin interaction

Article

Patent abstract

The present invention provides a method of inhibiting release of a virus from a cell, comprising contacting the cell with a compound that binds an ubiquitin E2 variant (UEV) domain of a cellular polypeptide, or fragment thereof, with an affinity sufficient to inhibit or disrupt the binding of the cellular polypeptide, or fragment thereof, to ubiquitin.

Infobox
Is a
Patent
Patent
0
Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
0
Patent Number
120594130
Patent Inventor Names
Carol Carter0
Lorna Erlich0
Madeleine Davison0
Nico Tjandra0
Date of Patent
August 13, 2024
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Patent Application Number
163426950
Date Filed
October 30, 2017
0
Patent Citations
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US Patent 7202329 Tsg101-GAGp6 interaction and use thereof
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US Patent 7235244 Compositions and methods for treating papillomavirus-infected cells
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US Patent 7335468 TSG101-GAG interaction and use thereof
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US Patent 7566455 E6AP-binding proteins
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US Patent 7572828 Identification of anti-HIV compounds inhibiting virus assembly and binding of nucleocapsid protein to nucleic acid
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US Patent 7625917 Thiolesters and uses thereof
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US Patent 7659277 Ubiquitin ligase inhibitors and methods related thereto
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US Patent 7714108 Mammalian tumor susceptibility gene products and their uses
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US Patent 7750134 Nucleic acids encoding microbial SUMO protease homologs
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US Patent 7776577 Ubiquitin protease
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US Patent 7943146 Immunizing compositions comprising HIV-1 proviral constructs with an inactive p6 gag TSG101 UEV binding domain capable of producing budding-defective viral particles that remain tethered to the cell surface
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US Patent 8021833 Method for reducing HIV viral budding by administering a VPS28-specfic antibody that disrupts Gag-TSG101-VPS28 binding interactions
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US Patent 8173657 Imidazoquinoxaline compounds as immunomodulators
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US Patent 8178494 Modified human growth hormone formulations with an increased serum half-life
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US Patent 8283355 Pyrimidine derivatives as POSH and POSH-AP inhibitors
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US Patent 8404747 Compositions and methods for modulating interaction between polypeptides
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US Patent 8476009 Methods for detecting enveloped virus infections by measuring cell surface TSG101
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US Patent 8518968 Hydrazone and diacyl hydrazine compounds and methods of use
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US Patent 11191741 Compounds and methods for the targeted degradation of enhancer of zeste homolog 2 polypeptide
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US Patent 8618042 Binding molecules and methods of use thereof
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US Patent 9175045 Peptidomimetic macrocycles
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US Patent 9464115 Stabilized alpha helical peptides and uses thereof
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US Patent 9492554 Methods and compositions related to viral inhibition
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US Patent 11220515 Imide-based modulators of proteolysis and associated methods of use
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US Patent 10022422 Peptidomimetic macrocycles
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US Patent 10071164 Estrogen-related receptor alpha based protac compounds and associated methods of use
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US Patent 10239888 Targeted protein degradation using a mutant E3 ubiquitin ligase
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US Patent 10266565 Peptide mimetic ligands of polo-like kinase 1 polo box domain and methods of use
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US Patent 10428060 PI-kinase inhibitors with anti-infective activity
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US Patent 10588902 Camptothecin derivatives as anti-HIV agents and methods of identifying agents that disrupt Vif self-association
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US Patent 10702526 Inhibitors of immune checkpoint modulators and related methods
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US Patent 10765687 Methods and compounds to inhibit enveloped virus release
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US Patent 10806737 Compounds and methods for the targeted degradation of fetal liver kinase polypeptides
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US Patent 10864248 Dab2 inhibitors for the prevention and treatment of cystic fibrosis
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US Patent 10954287 Ras binding peptides and methods of use
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US Patent 11028088 Modulators of BTK proteolysis and methods of use
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US Patent 11065231 Compounds and methods for the targeted degradation of interleukin-1 receptor- associated kinase 4 polypeptides
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US Patent 11338013 Combination therapy for C3 inhibition
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US Patent 11407789 Cell-penetrating compstatin analogs and uses thereof
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US Patent 11492590 Protein modification of living cells using sortase
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US Patent 11666562 Ilaprazole for inhibiting the release of enveloped viruses from cells
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Patent Primary Examiner
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Savitha M Rao
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CPC Code
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Y02A 50/30
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G01N 33/56983
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G01N 33/56988
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A61P 31/12
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A61K 31/4439
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