Patent 12018071 was granted and assigned to HCW Biologics Inc. on June, 2024 by the United States Patent and Trademark Office.
Provided herein are single-chain chimeric polypeptides that include: (i) a first target-binding domain; (ii) a soluble tissue factor domain; and (iii) a second target-binding domain. Also provided here are methods of using these single-chain chimeric polypeptides and nucleic acids encoding these single-chain chimeric polypeptides.