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US Patent 12012462 Chimeric receptors to DLL3 and methods of use thereof

Patent 12012462 was granted and assigned to Amgen on June, 2024 by the United States Patent and Trademark Office.

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Patent
Patent
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Patent attributes

Current Assignee
Amgen
Amgen
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
120124620
Patent Inventor Names
Michael John Giffin0
Ruben Alvarez Rodriguez0
Jun Feng0
Ryan B. Case0
Melissa Thomas0
Lawren Wu0
Christopher Murawsky0
Jed J. Wiltzius0
Date of Patent
June 18, 2024
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Patent Application Number
170467310
Date Filed
April 10, 2019
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Patent Citations
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US Patent 8436183 Synthetic multimerizing agents
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US Patent 8486693 Modified dendritic cells having enhanced survival and immunogenicity and related compositions and methods
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US Patent 9024028 Methods and compositions for the synthesis of multimerizing agents
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US Patent 10428142 Multipartite signaling proteins and uses thereof
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US Patent 9944690 Methods for controlling T cell proliferation
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US Patent 10934346 Modified T cell comprising a polynucleotide encoding an inducible stimulating molecule comprising MyD88, CD40 and FKBP12
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US Patent 6867041 Simultaneous stimulation and concentration of cells
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US Patent 6905874 Simultaneous stimulation and concentration of cells
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...
Patent Primary Examiner
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Peter J Reddig
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Patent abstract

Antigen binding molecules, chimeric receptors, and engineered immune cells to DLL3 are disclosed in accordance with the invention. The invention further relates to vectors, compositions, and methods of treatment and/or detection using the DLL3 antigen binding molecules and engineered immune cells.

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