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US Patent 11981923 Pepmixes to generate multiviral CTLS with broad specificity

Patent 11981923 was granted and assigned to Baylor College of Medicine on May, 2024 by the United States Patent and Trademark Office.

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Patent attributes

Patent Applicant

Baylor College of Medicine

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Current Assignee

Baylor College of Medicine

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Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Ann Marie Leen0

Juan Fernando Vera Valdes0

Ulrike Gerdemann0

Cliona M. Rooney0

Date of Patent

May 14, 2024

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Patent Application Number

176596240

Date Filed

April 18, 2022

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Patent Citations

US Patent 9115402 Compositions and methods of identifying tumor specific neoantigens

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US Patent 9255243 Cell culture methods and devices utilizing gas permeable materials

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US Patent 9963677 Generation of CTL lines with specificity against multiple tumor antigens or multiple viruses

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US Patent 10351824 Process of expanding T cells

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US Patent 10385316 Generation of CTL lines with specificity against multiple tumor antigens or multiple viruses

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US Patent 10556943 HLA-DR binding peptides and their uses

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US Patent 11111816 Rotor blade arrangement

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US Patent 11118164 Pepmixes to generate multiviral CTLs with broad specificity

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Patent Primary Examiner

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CPC Code

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Patent abstract

The present invention concerns methods of generating CTLs that are able to target at least one antigen from two or more viruses. The method includes exposing mixtures of peptides for different antigens to the same plurality of PBMCs and, at least in certain aspects, expanding the cells in the presence of IL4 and IL7.

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