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US Patent 11959105 Polymerizing enzymes for sequencing reactions

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 US Patent 11959105 Polymerizing enzymes for sequencing reactions

Article

Patent abstract

Compositions comprising modified recombinant polymerizing enzymes are provided, along with nucleic acid molecules encoding the modified polymerizing enzymes. In some aspects, methods of using such polymerizing enzymes to synthesize a nucleic acid molecule or to sequence a nucleic acid template are provided.

Infobox
Is a
Patent
Patent
0
Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
119591050
Patent Inventor Names
Brian Reed0
Manjula Pandey0
Date of Patent
April 16, 2024
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Patent Application Number
169141950
Date Filed
June 26, 2020
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Patent Citations
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US Patent 7229799 System and method for nucleic acid sequencing by polymerase synthesis
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US Patent 7361466 Nucleic acid analysis using terminal-phosphate-labeled nucleotides
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US Patent 7968702 Labeled reactants and their uses
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US Patent 8034623 Method for free radical initiated peptide sequencing
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US Patent 8084734 Laser desorption ionization and peptide sequencing on laser induced silicon microcolumn arrays
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US Patent 8153375 Compositions and methods for nucleic acid sequencing
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US Patent 8192961 System and methods for nucleic acid sequencing of single molecules by polymerase synthesis
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US Patent 8252910 Modular nucleotide compositions and uses therefor
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US Patent 8257954 Generation of modified polymerases for improved accuracy in single molecule sequencing
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US Patent 8309330 Diagnostic sequencing with small nucleic acid circles
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US Patent 8354252 Labeled reactants and their uses
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US Patent 8404808 Phage phi29 DNA polymerase chimera
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US Patent 8420366 Generation of modified polymerases for improved accuracy in single molecule sequencing
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US Patent 8455193 Compositions and methods for nucleic acid sequencing
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US Patent 8530154 System and method for nucleic acid sequencing by polymerase synthesis
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US Patent 8581179 Protein sequencing with MALDI mass spectrometry
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US Patent 8846881 Modular nucleotide compositions and uses therefor
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US Patent 8906614 Labeled reactants and their uses
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US Patent 8927212 FRET-labeled compounds and uses therefor
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US Patent 8980584 System and methods for nucleic acid sequencing of single molecules by polymerase synthesis
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US Patent 9062091 Polymerase enzyme substrates with protein shield
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US Patent 9404146 Compositions and methods for nucleic acid sequencing
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US Patent 9435810 Molecules and methods for iterative polypeptide analysis and processing
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US Patent 9464107 Labeled nucleotide analogs
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US Patent 9542527 Compositions and methods for nucleic acid sequencing
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US Patent 9551031 Modular nucleotide compositions and uses therefor
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US Patent 9551660 Method for detecting reactants using fluorescent signal intensity
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US Patent 9566335 Protein sequencing method and reagents
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US Patent 9582640 Methods for obtaining a single molecule consensus sequence
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US Patent 9600626 Methods and systems for obtaining a single molecule consensus sequence
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US Patent 9678080 Bis-biotinylation tags
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US Patent 9719073 Recombinant polymerases for improved single molecule sequencing
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US Patent 9845501 System and methods for nucleic acid sequencing of single molecules by polymerase synthesis
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US Patent 9879319 Modular nucleotide compositions and uses therefor
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US Patent 9910956 Sequencing using concatemers of copies of sense and antisense strands
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US Patent 9957291 Protected fluorescent reagent compounds
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US Patent 10023605 Labeled nucleotide analogs having protein shields
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US Patent 10066258 FRET-labeled compounds and uses therefor
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US Patent 10150872 Multimeric protected fluorescent reagents
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US Patent 10161002 Modular nucleotide compositions and uses therefor
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US Patent 10481162 Protein sequencing method and reagents
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US Patent 10544449 Bis-biotinylation tags
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US Patent 10545153 Single molecule peptide sequencing
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US Patent 10570445 Fret-labeled compounds and uses therefor
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US Patent 10676788 Modified nucleotide reagents
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US Patent 10745750 Modular nucleotide compositions and uses therefor
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US Patent 10787573 Multimeric protected fluorescent reagents
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US Patent 11312944 Polymerizing enzymes for sequencing reactions
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US Patent 6846638 Method and system for rapid biomolecular recognition of amino acids and protein sequencing
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US Patent 6869764 Nucleic acid sequencing using charge-switch nucleotides
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US Patent 6936702 Charge-switch nucleotides
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US Patent 7052847 Method for sequencing nucleic acid molecules
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US Patent 7056661 Method for sequencing nucleic acid molecules
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Patent Primary Examiner
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Todd M Epstein
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