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US Patent 11958861 Spirocyclic lactams as JAK2 V617F inhibitors

Patent 11958861 was granted and assigned to Incyte on April, 2024 by the United States Patent and Trademark Office.

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 US Patent 11958861 Spirocyclic lactams as JAK2 V617F inhibitors

Article

Patent abstract

The present application provides spirocyclic lactam compounds that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer.

Infobox
Is a
Patent
Patent
0
Patent Applicant
Incyte
Incyte
0
Current Assignee
Incyte
Incyte
0
Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
119588610
Patent Inventor Names
Charles Cole0
Darius Vrubliauskas0
Eddy W. Yue0
Kai Liu0
Liangxing Wu0
Lixin Shao0
Nikoo Falahatpisheh0
Stacey Shepard0
Wenqing Yao0
Date of Patent
April 16, 2024
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Patent Application Number
176800020
Date Filed
February 24, 2022
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Patent Citations
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US Patent 7429456 Identification of a JAK2 mutation in Polycythemia Vera
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US Patent 7781199 Identification of a JAK2 mutation involved in Vaquez Polyglobulia
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US Patent 7879844 Heterocyclic janus kinase 3 inhibitors
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US Patent 8163767 Heterocyclic Janus Kinase 3 inhibitors
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US Patent 8524867 Optimized antibodies that target CD19
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US Patent 8637235 Identification of a JAK2 mutation in polycythemia vera
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US Patent 8785639 Substituted dihydropyrazolo[3,4-D]pyrrolo[2,3-B]pyridines and methods of use thereof
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US Patent 8852931 Identification of a JAK2 mutation involved in vaquez polyglobulia
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US Patent 9115133 Substituted fused tricyclic compounds, compositions and medicinal applications thereof
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US Patent 9233985 Arginase inhibitors as therapeutics
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US Patent 9321730 Method of making and administering quinoline derivatives as anti-cancer agents
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US Patent 9493419 Quinoline derivatives as anti-cancer agents
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US Patent 10065974 Compositions and methods for inhibiting arginase activity
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US Patent 10155987 Methods of predicting resistance to JAK inhibitor therapy
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US Patent 10287303 Compositions and methods for inhibiting arginase activity
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US Patent 10377759 Brk inhibitory compound
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US Patent 11753413 Substituted pyrrolo[2,1-f][1,2,4]triazine compounds as JAK2 V617F inhibitors
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US Patent 11767323 Tricyclic pyridone compounds as JAK2 V617F inhibitors
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US Patent 11780840 Tricyclic urea compounds as JAK2 V617F inhibitors
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US Patent 6951865 Fused heterotricyclic compounds, process for preparing the compounds and drugs containing the same
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Patent Primary Examiner
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Jeffrey H Murray
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CPC Code
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C07D 491/22
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C07D 471/22
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C07D 471/20
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A61K 31/506
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A61K 31/46
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A61K 31/438
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