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US Patent 11939365 T cell receptors recognizing mutated P53

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Patent attributes

Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Rami Yoseph0

Drew C. Deniger0

Maria R. Parkhurst0

Winifred M. Lo0

Steven A. Rosenberg0

Paul F. Robbins0

Yong-Chen Lu0

Anna Pasetto0

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Date of Patent

March 26, 2024

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Patent Application Number

166512420

Date Filed

September 17, 2018

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Patent Citations

US Patent 8034334 Immunotherapy with in vitro-selected antigen-specific lymphocytes after non-myeloablative lymphodepleting chemotherapy

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US Patent 8383099 Adoptive cell therapy with young T cells

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Patent Primary Examiner

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Patent abstract

Disclosed is an isolated or purified T cell receptor (TCR) having antigenic specificity for mutated human p53. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal.

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