Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Patricia Coromoto Biasutto0
Hee Lam Chan0
Date of Patent
March 5, 2024
0Patent Application Number
171447280
Date Filed
January 8, 2021
0Patent Citations
Patent Primary Examiner
Patent abstract
Antisense oligonucleotides target the mutation in intron 26 of the CEP290 gene and reduce inclusion of the aberrant exon into the CEP290 mRNA. The oligonucleotides include no more than 3 consecutive guanosines, have no more than 60% guanosine nucleobases, include at most one CpG sequence, and/or do not have the potential to form a hairpin comprising 3 or more consecutive complementary base pairs.
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