Is a
Patent attributes
Patent Applicant
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Hee Lam Chan0
Patricia Coromoto Biasutto0
Date of Patent
January 12, 2021
0Patent Application Number
165768530
Date Filed
September 20, 2019
0Patent Citations Received
Patent Primary Examiner
Patent abstract
Antisense oligonucleotides target the mutation in intron 26 of the CEP290 gene and reduce inclusion of the aberrant exon into the CEP290 mRNA. The oligonucleotides include no more than 3 consecutive guanosines, have no more than 60% guanosine nucleobases, include at most one CpG sequence, and/or do not have the potential to form a hairpin comprising 3 or more consecutive complementary base pairs.
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