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US Patent 11912778 Methods of engineering transferrin receptor binding polypeptides

Patent 11912778 was granted and assigned to Denali Therapeutics on February, 2024 by the United States Patent and Trademark Office.

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Patent
Patent
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Patent attributes

Patent Applicant
Denali Therapeutics
Denali Therapeutics
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Current Assignee
Denali Therapeutics
Denali Therapeutics
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
119127780
Patent Inventor Names
Mark S. Dennis0
Joy Yu Zuchero0
Ankita Srivastava0
Mihalis Kariolis0
Ryan J. Watts0
Adam P. Silverman0
Robert C. Wells0
Xiaocheng Chen0
Date of Patent
February 27, 2024
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Patent Application Number
178884060
Date Filed
August 15, 2022
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Patent Citations
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US Patent 8053567 Modified surface material, method for preparing same and uses thereof
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US Patent 8084254 Human blood brain barrier model
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US Patent 8088376 Fc variants with altered binding to FcRn
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US Patent 7241449 Transferrin receptor genes of
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US Patent 7371826 Polypeptide variants with altered effector function
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US Patent 7670600 Molecules with extended half-lives, compositions and uses thereof
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US Patent 7741446 Fusion antibodies that cross the blood-brain barrier in both directions
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US Patent 7744879 Blood-brain barrier targeting antibodies
0
...
Patent Primary Examiner
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Christian C Boesen
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Patent abstract

Provided herein are polypeptides that bind to a transferrin receptor, methods of generating such polypeptides, and methods of using the polypeptides to target a composition to a transferrin receptor-expressing cell.

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