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US Patent 11866742 Fusion proteins comprising enzyme replacement therapy enzymes

Patent 11866742 was granted and assigned to Denali Therapeutics on January, 2024 by the United States Patent and Trademark Office.

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Is a
Patent
Patent
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Patent attributes

Patent Applicant
Denali Therapeutics
Denali Therapeutics
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Current Assignee
Denali Therapeutics
Denali Therapeutics
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
118667420
Patent Inventor Names
Cathal S. Mahon0
Mihalis S. Kariolis0
Julie Ullman0
Ankita Srivastava0
Anastasia Henry0
Adam P. Silverman0
Date of Patent
January 9, 2024
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Patent Application Number
171021380
Date Filed
November 23, 2020
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Patent Citations
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US Patent 7871624 Chimeral polypeptide composition for cross-placenta delivery
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US Patent 7981864 Methods and compositions for targeting proteins across the blood brain barrier
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US Patent 8124073 Targeting of glycoprotein therapeutics
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US Patent 8128925 Manufacture of active highly phosphorylated human lysosomal sulfatase enzymes and uses thereof
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US Patent 8207114 Targeted therapeutic proteins
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US Patent 8227212 Cell that expresses a sulfatase and a formylglycine generating enzyme
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US Patent 8486399 Methods and compositions for increasing arylsulfatase A activity in the CNS
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US Patent 8536319 Compounds and methods for detecting ricin and uses thereof
0
...
Patent Primary Examiner
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Michael D Pak
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Patent abstract

Provided herein are fusion proteins that comprise an enzyme replacement therapy enzyme and an Fc region, as well as methods of using such proteins to treat a lysosomal storage disorder. Methods for transporting agents across the blood-brain barrier are also provided herein.

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